N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives

Details N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives

1991-03-22

1994-09-06

Bernhard, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D48704, A61K 31505

Patent

active

053449320

ABSTRACT:
N-(Acyl)glutamic acid derivatives in which the acyl group is substituted with 4-hydroxypyrrolo[2,3-d]-pyrimidin-3-yl group are antineoplastic agents. A typical embodiment is N-[4-(2-{4-hydroxy-6-aminopyrrolo-[2,3-d]pyrimidin-3-yl}ethyl)benzoyl]-L-g lutamic acid.

REFERENCES:
patent: 4889859 (1989-12-01), Taylor et al.
patent: 4996206 (1991-02-01), Taylor et al.
patent: 4997838 (1991-03-01), Akimoto et al.

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