Sialic acid glycosides, antigens, immunoadsorbents, and methods

Details Sialic acid glycosides, antigens, immunoadsorbents, and methods Sialic acid glycosides, antigens, immunoadsorbents, and methods

1992-03-17

1994-09-06

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 543, 536 53, 536 182, 536 187, 536 551, 536 553, 210656, 210660, C07H 1506, C07H 100

Patent

active

053448707

ABSTRACT:
The stereochemistry of sialylation of an acceptor saccharide to obtain an .alpha. (2-3) or .alpha. (2-6) linkage is controlled to favor the .alpha. anomer by use of an aromatic ester of the sialyl reagent. The resulting intermediate .alpha. (2-3) and .alpha. (2-6) sialylated intermediate disaccharide blocks are useful in the synthesis of antigenic substances which can be used to raise antibodies useful in diagnosis and therapy, and can themselves be used as reagents in various applications. The preparation of the tetrasaccharide antigens corresponding to the 19-9 and sialyl-X antigens characteristic of malignant tissue illustrates the application of this method.

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