DNA encoding an insect octopamine receptor

Details DNA encoding an insect octopamine receptor DNA encoding an insect octopamine receptor

1991-03-28

1994-09-06

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435 691, 4353201, 536 235, C12N 1512, C12N 1563

Patent

active

053447760

ABSTRACT:
The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.

REFERENCES:
Arakawa et al. Cloning Localization and Permanent Expression of a Drosophila Octopamine Receptor Mar., 1990. Neuron vol. 2 pp. 343-354.
Saudou et al. Cloning and characterization of a Drosophila tyramine receptor Nov., 1990 EMBO vol. 9 (11) pp. 3611-3617.

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