Retinoyloxy (alkyl-substituted) methyl butyrates useful for the

Details Retinoyloxy (alkyl-substituted) methyl butyrates useful for the Retinoyloxy (alkyl-substituted) methyl butyrates useful for the

1997-10-06

2000-03-28

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

A61K 31225

Patent

active

060432772

ABSTRACT:
This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising administering a compound of Formula (I) and pharmaceutically-acceptable salts and prodrugs thereof. ##STR1## The compounds of the invention are also useful in methods of ameliorating wrinkles, inducing wound healing, treating cutaneous ulcers and treating gastrointestinal disorders.

REFERENCES:
patent: 3882244 (1975-05-01), Lee
patent: 4054589 (1977-10-01), Bollag et al.
patent: 4105681 (1978-08-01), Bollag et al.
patent: 4215215 (1980-07-01), Bollag et al.
patent: 4677120 (1987-06-01), Parish et al.
patent: 4885311 (1989-12-01), Parish et al.
patent: 4900478 (1990-02-01), Gross
patent: 5124356 (1992-06-01), Purcell et al.
patent: 5158773 (1992-10-01), Gross
Feldman et al (1993) N. Engl. J. Med. 329: 177-89.
Collins SJ, et al., Int.J. Cancer 25: 213-218(1980).
Strickland S., et al., Cell 15: 393-403 (1978).
Chomienne, et al., Blood 76: No. 9 1710-1717 (1990).
Wright DG., Blood 67: No. 1 334-337 (1987).
Toscani, et al., Oncogene Res. 3: 228-238 (1988).
Prasad KN., et al., Biochem. Cell. Biol. 68: No. 11 1250-1255 (1992).
Rabizadeh E., et al., FEBS Lett. 328: No. 3 225-229 (1993).
Breitman, et al., Cancer Res. 50: 6268-6273 (1990).
Warrell RP. Jr., et al., N. Engl. J. Med. 324/20: 1385-1393 (1991).
Adamson PC., et al., Journal of the National Cancer Institute 85/12: 993- (1993).
Reese et al. (1985) Cancer Res. 45: 2308-2313.
Reiss et al. (1986) Cancer Treat. Rep. 70:201-218.

Affiliated with

Also associated with

Rating

Retinoyloxy (alkyl-substituted) methyl butyrates useful for the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Retinoyloxy (alkyl-substituted) methyl butyrates useful for the , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Retinoyloxy (alkyl-substituted) methyl butyrates useful for the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1326442