Carboline derivatives

Details Carboline derivatives Carboline derivatives

1998-09-16

2000-03-28

Jones, Dwayne C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 85, A61K 3144

Patent

active

060432527

ABSTRACT:
Carboline derivatives of formula (I) ##STR1## are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP-specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.

REFERENCES:
patent: 4801587 (1989-01-01), Voss et al.
patent: 5770606 (1998-06-01), El-Rashidy et al.
patent: 5874437 (1999-02-01), Garvey et al.

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