Positively charged non-natural amino acids, methods of making th

Details Positively charged non-natural amino acids, methods of making th Positively charged non-natural amino acids, methods of making th

1996-10-22

2000-03-28

Huff, Sheela

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

436 86, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530331, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, A61K 3800

Patent

active

060432187

ABSTRACT:
This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides. In one embodiment, the invention relates to non-natural amino acids that closely replicate the natural amino acids lysine and arginine.

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Yokoi et al, Neuropharmacology, vol. 33 pp. 1261 (Abst. Only), 1994.
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Nestor, Jr. et al, J. Med. Chem., vol. 31 p. 65, 1988.
Lindeberg, et al, Solid Phase Synthesis And Some Hormonal Activities of 1-Deamino-4-L-Valine-8-D-Homolysine-And 1-Deamino-4-L-Valine-8-D-Homoarginine-Vasapressin, Int. J. Peptide Protein Res. 10, 240-244, 1977.
Moore, et al., Effect of the basic amino-acid side chain length and the penultimate residue on the hydrolysis of benzoyldipeptides by carboxpeptidbase B.sup.1, Can. J. Biochem, 56, 315-318, 1978.
Nestor, et al., Potent, Long-Acting Luteinizing Hormone-Releasing Hormone Antagonist Containing New Synthetic Amino Acids: N,N-Dialkyl-D-homoarginines .sup.1, J. Med. Chem, 31, 65-72, 1988.
Hilbert, et al., Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors, J. Med. Chem. 37, 3889-3901, 1994.

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