Carboxylic acid derivatives, and pharmaceutical compositions con

Details Carboxylic acid derivatives, and pharmaceutical compositions con Carboxylic acid derivatives, and pharmaceutical compositions con

1988-01-12

1992-09-08

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

554 94, 554 95, 554101, 554102, 554108, 554109, 554218, 514866, 514574, 514560, 514552, 514550, 514549, 514543, 562429, 562470, 562587, 562588, 564162, 564182, 564191, 564192, 560 11, 560 15, 560150, 560152, 560155, 560170, C07C31300, C07C30900, C07C31744, C07C32102

Patent

active

051456117

ABSTRACT:
Carboxylic acid derivatives of the formula ##STR1## R.sub.1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamino. R.sub.2 is optionally substituted aryl or, when B is alkylene also a hydrogen atom. A is a straight-chained or branched, saturated or unsaturated alkylene containing 3 to 10 carbon atoms which is optionally interrupted by a heteratom attached to a saturated carbon and has a chain length of at least 3 atoms. Y is S(O).sub.n group or oxygen, n being 0, 1 or 2. B is a valency bond or a straight-chained or branched, saturated or unsaturated alkylene containing 1 to 18 carbon atoms. Physiologically acceptable salts, esters and amides thereof are also included. The compounds are useful in the treatment of metabolic diseases.

REFERENCES:
patent: 3562330 (1971-02-01), Nordin
Doyle et al., Chemical Abstracts, vol. 100:208635b, 1984.
Ager, "The Ester Enolate Claisen Rearrangement of Allyl . . . ", Tetrahedron Letters, 23, 3419-20 (1982).
Lythgoe et al., "A New 1,2-Elimination Reaction with a Radical . . . ", Tetrahedron Letters, No. 48, 4223-4226 (1977).
Trost et al., "Macrolide Formation via an Isomerization Reaction . . . ", J. Am. Chem. Soc., 105, 5940-42 (1983).
Abstract: Prasad et al., "Potential antitubecular drugs, Part I. Synthesis of Derivatives . . . ", C.A. 90:49008f (1979).
Trost et al., "Synthesis of Thermodynamically Less Stable Enol Thioethers. An Alternative Oxidative Decarboxylation of .alpha.-Thio Acids", J. Org. Chem., 43, 4549-51 (1978).
Trost et al., "Tungsten-Catalyzed Allylic Alkylations. New Avenues for Selectivity", J. Am. Chem. Soc., 105, 7757-9 (1983).

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