Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...
Patent
1998-08-28
2000-03-28
Saunders, David
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Animal cell, per se, expressing immunoglobulin, antibody, or...
435336, 53038823, 53038824, C12N 506, C07K 1624, C07K 1625
Patent
active
060430869
ABSTRACT:
The present invention relates to the identification and characterization of a novel, membrane-anchored chemokine, neurotactin. Sequence analysis of neurotactin reveals that, while it includes an amino terminal domain which resembles that of other chemokines, it has an overall structure which distinguishes it from all presently identified chemokines. Neurotactin is highly expressed in normal mammalian brain. Inhibitors of neurotactin expression or activity can be used to treat inflammation.
REFERENCES:
Baggiolini et al., "CC chemokines in allergic inflammation" Immun. Today 15:(3)127-133, 1994.
Barthalay et al., "Drosophila neurotactin mediates heterophilic cell Adhesion" EMBO Journal 9:(11)3603-3609, 1990.
Burkly et al., "T-Cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression: . . . " Nature 342:564-566, 1989.
Cocket et al., "The use of engineered E1A genes to transactivate the hCMV-MIE promoter in permanent CHO cell lines" Nucl. Acids Res. 19:319-325, 1991.
Kelner et al., "Lymphotactin: A cytokine that represents a new class of cemokine" Science 266:1395-1399, 1994.
Massague et al., "Membrane-Anchored Growth Factors" Annu. Rev. Biochem. 62:515-41, 1993.
Owens et al., "Inflammatory cytokines in the brain: does the CNS shape immune responses?" Immun. Today 15: (12)566-571, 1994.
Pan et al., "Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation" Nature 387: 611-617, 1997.
Rowland, L., "Blood-Brain Barrier, Cerbrospinal Fluid, Brain Edema, and Hydrocephalus" Appendix, Brain Fluids and Their Disorders, pp. 837-844.
Santiago et al., "Characterization and gene cloning of neurotactin, a Drosophila transmembrane protein related to cholinesterases" EMBO Journal 9:3593-3601, 1990.
Millenium BioTherapeutics, Inc.
Saunders David
VanderVegt F. Pierre
LandOfFree
Neurotactin and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Neurotactin and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Neurotactin and uses therefor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1325282