Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-06-30
1999-11-16
Dodson, Shelley A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
424400, 424464, 514859, A61K 31275, A61K 900, A61K 920
Patent
active
059858680
ABSTRACT:
Methods and compositions are disclosed utilizing optically pure R-(-)-casodex for the treatment of androgen-dependent prostate cancer, while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of casodex. R-(-)-casodex is an antiandrogen and is therefore useful in the treatment of other conditions supported by androgen or caused by elevated androgen levels. Such conditions include benign prostatic hypertrophy or hyperplasia, acne and hirsutism.
REFERENCES:
Kennealey et al., "Use of the Nonsteroidal Anti-androgen Casodex in Advanced Prostatic Carcimona", Urologic Clinics of North America, V. 18, No. 1, pp. 99-110, 1991.
Furr, "Casodex (ICI 176,334)--A New, Pure, Peripherally-Selective Anti-Androgen:Preclinical Studies", Horm Res, V. 32 (suppl 1), pp. 69-76, 1989.
Cockshott et al., "The Pharmacokinetics of Casodex Enantiomers in Subjects With Impaired Liver Function", Br J Clin Pharmac, V. 36, pp. 339-343, 1993 .
Dodson Shelley A.
Lamm Marine
Sepracor Inc.
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