Hybridoma cell line XMMBR-B14 and monoclonal antibody which is s

Details Hybridoma cell line XMMBR-B14 and monoclonal antibody which is s Hybridoma cell line XMMBR-B14 and monoclonal antibody which is s

1988-02-16

1989-08-01

Moskowitz, Margaret

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

4351722, 43524027, 530806, 530828, 530395, 424 858, A61K 39395, C07K 1514, C12N 1500

Patent

active

048534641

ABSTRACT:
The present invention provides a novel hybridoma cell line secreting monoclonal antibodies (MoAbs) that define an epitope found on an antigen of the classification termed CEA/NCA (carcinoembryonic antigen
ormal cross-reacting antigen). The MoAbs of the invention find particular utility as the targeting moiety of immunotoxin and immunoimaging conjugates.
Hybridoma XMMBR-B14 was deposited with the A.T.C.C. on Jan. 14, 1987 and given A.T.C.C. Accession No. HB 9308.

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Thorpe et al., Immunol Rev., 62, 136 (1982).
Haspel et al., in "Monoclonal Antibodies and Cancer Therapy", p. 505-522 (Reisfeld and Sell, Ed's), A. R. Liss, Inc., NY (1985).
Price et al., IRCS Med. Sci., 13, 366-367 (1985).
Griffin et al., INCI, 69, 799 (1982).
Mach, J. P. et al., N. Eng. J. Med., 303, 5-10 (1980).
Goldenberg et al., N. Eng. J. Med., 298, 1384 (1978).
Price, Br. J. Cancer; 57, 165-9 (1988).
Kohler and Milstein, NATURE (1975), 256:495-97.
EPO Publication No. 0088695.
Price and Baldwin, ICRS MED. SCI. (1984), 12:1000-01.

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