Substituted 3-(aminoalkylamino)-1, 2-benzisoxazoles and related

Details Substituted 3-(aminoalkylamino)-1, 2-benzisoxazoles and related Substituted 3-(aminoalkylamino)-1, 2-benzisoxazoles and related

1997-03-18

1999-07-20

Powers, Fiona T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548241, 5483625, C07D26120, C07D27504, C07D23156

Patent

active

059257660

ABSTRACT:
This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful or the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.

REFERENCES:
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patent: 3707364 (1972-12-01), Becke et al.
patent: 3725431 (1973-04-01), Gschwend
patent: 4533731 (1985-08-01), Ibuki et al.
patent: 4844728 (1989-07-01), Yamamoto et al.
patent: 5494908 (1996-02-01), O'Malley et al.
patent: 5580982 (1996-12-01), O'Malley et al.
Zani et al., II Farmaco, 44(10), 997-1006, 1989.

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