Method for preparing N.sup.2 -arylsulfonyl-L-argininamides

Details Method for preparing N.sup.2 -arylsulfonyl-L-argininamides Method for preparing N.sup.2 -arylsulfonyl-L-argininamides

1997-08-04

1999-07-20

Mach, D. Margaret M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514311, 514314, C07D21536

Patent

active

059257601

ABSTRACT:
A method for preparing N.sup.2 -(3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl)-N.sup.G -nitro-L-arginine which comprises the step of condensing N.sup.G -nitro-L-arginine and 3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl chloride. The method achieves an extremely efficient and high yield preparation of N.sup.2 -arylsulfonyl-L-arginineamides that are useful as active ingredients of medicaments. Also provided is a novel N.sup.2 -(3-(a hydrogen atom or a lower alkyl)-8-quinolinesulfonyl)-N.sup.G -nitro-L-arginine compound which can be used as synthetic intermediate for the manufacture of -(3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L-arginyl!-2-piperidine -carboxylic acid.

REFERENCES:
patent: 4101653 (1978-07-01), Okamoto

Affiliated with

Also associated with

Rating

Method for preparing N.sup.2 -arylsulfonyl-L-argininamides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for preparing N.sup.2 -arylsulfonyl-L-argininamides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for preparing N.sup.2 -arylsulfonyl-L-argininamides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1322937