All-trans-retinol metabolite

Details All-trans-retinol metabolite All-trans-retinol metabolite

1997-09-11

1999-03-09

Dees, Jose'G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 29, 549 78, 514438, C07D33310, A61K 3138

Patent

active

058802924

ABSTRACT:
In vitro incubation of all-trans-retinol (atROL) with kidney homogenate from vitamin A deficient and retinoic acid supplemented (VAD-RAS) female rats produced a new retinol metabolite. The metabolite has the structure ##STR1## and is believed useful for the treatment of skin disorders such as acne, psoriasis, and ultraviolet light skin damage, as well as for promoting female fertility and the maintenance of pregnancy.

REFERENCES:
patent: 4190594 (1980-02-01), Gander et al.
patent: 4459404 (1984-07-01), Frickel et al.
patent: 4568757 (1986-02-01), Carroll et al.
patent: 4757140 (1988-07-01), DeLuca et al.
Retinal, The Merck Index, 1989, pp. 1298-1299, No. 8165.
Vitamin A, The Merck Index, 1989, pp. 1576, No. 9918.
Retinoic Acid, The Merck Index, 1989, pp. 1298-1299, No. 8167.

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