Lacrimation accelerating agent

Details Lacrimation accelerating agent Lacrimation accelerating agent

1997-06-16

1999-07-20

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514651, A61K 31235, A61K 3124, A61K 31135

Patent

active

059256770

ABSTRACT:
A lacrimation accelerating agent containing a ligand of serotonin receptor as an active ingredient. Also provided is a method for preventive and/or therapeutic treatment of a disease caused by a deficiency of lacrimal fluid such as dry eye, which comprises the step of administering to a mammal an effective amount of a ligand of a serotonin receptor such as sarpogrelate hydrochloride.

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patent: 5244902 (1993-09-01), Sharpe et al.
Katzung,Basic & Clinical Pharmacology,Sixth Edition,p. 143, 1995.
Zifa et al., Pharmacological Reviews, vol. 44, No. 3 (1962), pp. 401 and 424-432.
Ali et al., Database Medline Accession No. 89297619, XP002041344 (Abstract) Rev. Elev. Med. Vet. Pays Trop., vol. 42, No. 1, 1989, pp. 13-17.
Adeghate et al., Biogenic. Amines, vol. 10, No. 2, pp. 487-498 (1994).

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