Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

1997-04-01

1999-07-20

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142278, 514314, 514326, 514327, 514330, 514341, 514444, 514445, 514447, 514448, 5462727, 546156, 546210, 548520, 5483365, 548197, 548484, 549 63, 549 64, 549 65, 549 66, 558416, A61K 3147, A61K 3144, C07D23361, C07C25504

Patent

active

059256516

ABSTRACT:
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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