Tricyclic N-cyanoimines useful as inhibitors of a farnesyl-prote

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5142328, 514255, 544126, 544361, 546 93, A61K 3144, C07D40104

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active

059256486

ABSTRACT:
Novel tricyclic N-cyanoimine compounds and pharmaceutical compositions of formula (1.0) ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein a, b, c, d, R.sup.1 -R.sup.8, X and Z are defined herein. Such compounds are inhibitors of the enzyme, farnesyl protein transferase. The compounds are useful for inhibiting Ras function and therefore inhibiting the abnormal growth of cells, in a mammals such as a human.

REFERENCES:
patent: 3975530 (1976-08-01), Durant et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5192537 (1993-03-01), Osband
Cecil Textbook of Medicine, edited by Wyngaarden, J.B. et al., 19th edition, W.B. Saunders Co., pp. 827-831 and 2304-2305, 1992.

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