Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-t

Details Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-t Process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-t

1995-02-01

1996-09-10

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

C07F 708, C07F 718

Patent

active

055547800

ABSTRACT:
The present invention relates to a novel process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia as disclosed by Schirlin, et al. in European Patent Application Publication No. 0 409 676, published Jan. 23, 1991.

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Kerdesky, A. A. J. et al., Tetrahedron Letters, vol. 32, pp. 2003-2004 (1991).
Yamakawa, T. et al, J. Med Chem 1990, vol. 33 pp. 1430-1437.
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Koser, G. F. et al., J. Org. Chem., vol. 45, pp. 1543-1544 (1980).
Sniekus, V. Chem. Rev., vol. 90, pp. 879-933 (1990).

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