N-trityl protected aspartic acid derivatives for the preparation

Details N-trityl protected aspartic acid derivatives for the preparation N-trityl protected aspartic acid derivatives for the preparation

1995-05-12

1996-09-10

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Acyclic carbon bonded directly to three benzene rings or to...

558169, C07F 940

Patent

active

055547737

ABSTRACT:
The present invention related to novel (R)-dimethyl N-tritylaspartate and novel (R)-alkyl N-trityl-4-oxo-5-phosphononorvalinate derivatives which are useful in the preparation of the class of beta-ketophosphonate NMDA antagonists.

REFERENCES:
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patent: 5179085 (1993-01-01), Bigge et al.
Tetrahedron Letter, vol. 28, No. 6, pp. 611-612, 1987, P. K. Chakravarty, et al.
J. Org. Chem. 1986, 51, 3882-3890; Paul L. Feldman, et al.
J. Org. Chem., 1990, 55, 3068-3074, Peter Gmeiner, et al.
Baldwin et al., Tetrahedron, 44 (2), pp. 637-642 (1988).
Webb et al., J. Org. Chem, 34 (3), pp. 576-580 (1969).

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