Biheteroaryl inhibitors of farnesyl-protein transferase

Details Biheteroaryl inhibitors of farnesyl-protein transferase Biheteroaryl inhibitors of farnesyl-protein transferase

1997-04-01

1999-03-09

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514269, 514334, 514335, 544298, 544331, 544333, 544335, 546256, 546257, 546261, 546262, A61K 3144, C07D40114

Patent

active

058801405

ABSTRACT:
The present invention is directed to compounds of the formula A which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras: ##STR1## The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

REFERENCES:
patent: 5346899 (1994-09-01), Mueller et al.
patent: 5691339 (1997-11-01), Shinayama

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