Triaryl substituted imidazoles as glucagon antagonists

Details Triaryl substituted imidazoles as glucagon antagonists Triaryl substituted imidazoles as glucagon antagonists

1997-11-17

1999-03-09

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462741, A61K 3144, C07D40104

Patent

active

058801391

ABSTRACT:
2,4-Diaryl-5-pyridylimidazoles are glucagon antagonists. The compounds block the action of glucagon at its receptor. Thus, the compounds can be used in the prophylaxis or treatment of disease states in mammals mediated by elevated levels of glucagon. Examples of such disease states include diabetes, obesity, hypertension, and cachexia and the like.

REFERENCES:
patent: 3772441 (1973-11-01), Lombardino
patent: 3929807 (1975-12-01), Fitzi
patent: 5620999 (1997-04-01), Weier et al.
patent: 5686455 (1997-11-01), Adams et al.

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