Nucleic acid encoding human phosphodiesterase regulatory subunit

Details Nucleic acid encoding human phosphodiesterase regulatory subunit Nucleic acid encoding human phosphodiesterase regulatory subunit

1997-05-05

1999-07-20

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 536 231, 536 235, 536 2431, C07H 2104, C12N 510, C12P 1563, C12P 2102

Patent

active

059255420

ABSTRACT:
The invention provides a new human phosphodiesterase regulatory subunit (HPRS) and polynucleotides which encode HPRS. The invention also provides expression vectors, host cells, agonists, the complement of the polynucleotide sequence and antibodies. The invention also provides methods for treating disorders associated with expression of HPRS.

REFERENCES:
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Beavo, J.A. "Cyclic Nucleotide Phosphodiesterases: Functional Implications of Multiple Isoforms." Physiological Reviews (1996) 75(4) :725-48.
Stryer, L. "Visual Excitation and Recovery" J.Biol.Chem. (1991) 266(17):10711-10714.
Florio, S.K. et al., "Solubilization of Membrane-bound Rod Phosphodiesterase by the Rod Phosphodiesterase Recombinant .delta. Subunit." J.Biol.Chem. (1996) 271(39):24036-24047. (GI 1565306).
Angel, J.B. et al., "Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication." AIDS (1995) 9(10):1137-1144.
Sommer, N. et al., "The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis." Nat.Med. (1995) 1(3):244-248.
Bang, Y.J. et al., "Terminal neuroendocrine differentiation of human prostate carcinoma cells in response to increased intracellular cyclic AMP." Proc.Natl.Acad.SciUSA (1994) 91(12):5330-5334.
Wilson, R. et al. (GI 540265), GenBank Sequence Database (Accession U14635), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894. (GI 540267).
GenBank Submission, Locus N58910, NIDg 1202800, Feb. 23, 1996.
GenBank Submission, Locus AA 112714, NID g 1663814, Nov. 8, 1996.
GenBank Submission, Locus BTPDEDIA, NID g 1565305, Sep. 28, 1996.
Fong, NAR 20(11) 2865-2870 (1992).
Sambrook et al "Molecular Cloning: A Laboratory Manual" (1989) 2.sup.nd Edition, Cold Spring Harbor Laboratory Press USA pp. 8.46-8.47; 9.2-9.3; 16.3-16.4; 17.2.

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