Ester of acetyl carnitine, processes for its preparation and pha

Details Ester of acetyl carnitine, processes for its preparation and pha Ester of acetyl carnitine, processes for its preparation and pha

1985-06-20

1988-05-10

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560170, C07C10118, A61K 3122

Patent

active

047436212

ABSTRACT:
Carnitine acetyl carnitate dichloride, a precursor of carnitine and acetyl carnitine, is prepared by condensing noncarnitine tert-butyl ester with the acid chloride of acetyl carnitine chloride and methylating the product of the condensation with methyl iodide, thereby obtaining acetyl carnitate of carnitine chloride iodide. This product is hydrolized with trifluoroacetic acid, thereby eliminating the tert-butyl ester. The so-obtained acetyl carnitate of carnitine chloride iodide is converted into the desired compound by eluting a solution of the chloride iodide on a strongly basic ion-exchange resin activated in Cl.sup.- form.

REFERENCES:
patent: 4439438 (1984-03-01), Cavazza
patent: 4443475 (1984-04-01), Cavazza
patent: 4551477 (1985-11-01), Cavazza
Wagner, "Synthetic Organic Chemistry," pp. 479-482, (1953).
Comber, Org. Prep. Proced. Int., 17, pp. 175-181, (1985).
McOmie, "Protective Groups in Organic Chemistry," pp. 183-185 & 192-196, (1973).

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