Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-07-28
1988-05-10
Siegel, Alan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514357, 514399, 514415, 514427, 514471, 514521, 514523, 546 21, 546 22, 546329, 546334, 546335, 548111, 548112, 548341, 548412, 548413, 548414, 548503, 548561, 549 6, 549 74, 549 75, 549 77, A61K 3138, A61K 3134, C07C 906, C07D21170
Patent
active
047436182
ABSTRACT:
Novel compounds useful as dopamine receptor agonists for the treatment of various diseases of the central nervous system such as Parkinson's disease and related disorders having the structural formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H, and OA; A is selected from the group consisting of hydrocarbyl radicals; ##STR2## where X is S or O: and pharmaceutically acceptable salts thereof. Also disclosed is a method for inducing a dopaminergic response in a patient by adminstering a pharmacologically-effective amount of one of the foregoing compounds.
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VanOene Joop C. et al., In Vivo Dopamine Autoreceptor Selectivity Appears to be Critically Dependent Upon the Aromatic Hydroxyl Position in a Series of N,N-Disubstituted 2-Aminotetralins., European Journal of Pharmacology, 102 (1984) pp. 101-115.
Baran Robert J.
Bostich June M.
Nelson Research & Development Co.
Siegel Alan
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