Saturated fatty acid amides as inhibitors of acyl-coa:cholestero

Details Saturated fatty acid amides as inhibitors of acyl-coa:cholestero Saturated fatty acid amides as inhibitors of acyl-coa:cholestero

1987-10-01

1988-05-10

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544319, 544301, 544311, A61K 31505, C07D23946, C07D23934, C07D23928

Patent

active

047436050

ABSTRACT:
Certain substituted amides of saturated fatty acids are potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase and are thus useful agents for inhibiting the intestinal absorption of cholesterol.

REFERENCES:
patent: 4250178 (1981-02-01), Bucher et al.
patent: 4410697 (1983-10-01), Torok et al.
Chem. Abstracts, vol. 76, No. 3, 14463j.
Chem. Abstracts, Volkenshtein et al., vol. 104, 199590m, (1986).
Chem. Abstracts, Boyes et al., vol. 94, 121134w, (1981).

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