Polypeptides that stimulate bone growth

Details Polypeptides that stimulate bone growth Polypeptides that stimulate bone growth

1995-06-07

1999-03-09

Jones, W. Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 530300, 530324, 530326, A61K 3804, A61K 3800, C07K 708, C07K 1451

Patent

active

058800948

ABSTRACT:
Polypeptides which stimulate bone growth are described based on the sequences: (a) Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala Glu Thr Leu Met Val; (b) Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu His Lys Lys Ala Ala; (c) Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile Lys Pro Asn Thr Leu; and (d) Gly Ile Gly Lys Arg Thr Asn Glu His Thr Ala Asp Cys Lys Ile. The associated nucleotide sequences, methods of preparation and use, and antibodies and kits based upon them are described, as well.

REFERENCES:
patent: 5461034 (1995-10-01), Rodan et al.
patent: 5578569 (1996-11-01), Tam
Castor et al. (1992) Arthritis and Rheumatism 35:782-93.
Walz and Baggiolini (1990) J. Exp. Med. 171:449-54.
Begg et al. (1978) Biochemistry 17:1739-44.
Castor et al. (1983) Proc. Natl. Acad. Sci. USA 80:765-69.
Castor et al. (1989) Biochem. Biophys. Res. Commun. 163:1071-78.

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