Inhibiting HMG-CoA reductase with novel substituted 2-pyridones

Details Inhibiting HMG-CoA reductase with novel substituted 2-pyridones Inhibiting HMG-CoA reductase with novel substituted 2-pyridones

1989-11-27

1991-07-16

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 546 14, 546268, 546302, C07D21194, A61K 3144, A61K 31535

Patent

active

050326023

ABSTRACT:
For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic,

REFERENCES:
Chem. Abstracts, 104:129776, Weber et al., Decker Oxidation of 2-Substituted N-alkylpyridinium Compounds, Chem. Ber., 1985, 118(10), p. 4086.

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