Use of leflunomide for inhibiting interleukin 1 alpha

Details Use of leflunomide for inhibiting interleukin 1 alpha Use of leflunomide for inhibiting interleukin 1 alpha

1995-06-05

1996-09-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3142

Patent

active

055546374

ABSTRACT:
N-(4-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide is an effective compound for preventing and treating disorders in which interleukin 1 alpha is involved. It is used as a pharmaceutical.

REFERENCES:
patent: 4351841 (1982-09-01), Kammerer et al.
patent: 4965276 (1990-10-01), Bartlett et al.
patent: 5397789 (1995-03-01), Carr et al.
M. Chan, "Inhibition of Tumor Necrosis Factor By Curcumin, A Phyto-chemical," Biochem. Pharmacology, vol. 49, No. 11, pp. 1551-1556 (1995).
Wong et al., "Interleukin (IL) 4 Differentially Regulates Monocyte IL-1 Family Gene Expression and Synthesis In Vitro and In Vivo," The Journal of Experimental Medicine, vol. 177, pp. 775-781 (1993).
European Search Report dated Jul. 15,1994.
Glant et al., Immunopharmacology, 23, 1992, pp. 105-116.
Zielinski et al., Immunobiology, 186(1-2), 1992, p.113.
Zielinski et al., Agents Actions, 38, 1993, pp. C80-C82.
Mattar et al., FEBS Letters, 334(2) 1993, pp. 161-164.
Durum et al., "Interleukin 1: An Immunological Perspective", Ann. Rev. Immunol., 3:263-287 (1985).
Tiku et al., "Interleukin 1 Production By Human Polymorphonuclear Neutrophils", J. Immunol., 136(10):3677-3685 (1986).
Oppenheim et al., "There Is More Than One Interleukin 1", Immunology Today, 7(2):45-56 (1986).
Symons et al., "Interleukin 1 In Rheumatoid Arthritis: Potentiation Of Immune Responses Within The Joint", Lymphokine Research, 893):365-372 (1989).
Boraschi et al., "Differential Activity Of Interleukin 1.alpha. And Interleikin 1.beta. In The Stimulation Of The Immune Response In Vivo", Eur. J. Immunol., 20:317-321 (1990).
Bartlett et al., "Leflunomide (HWA 486), A Novel Immunomidulating Compound For The Treatment Of Autoimmune Disorders And Reactions Leading To Transplantation Rejection", Agents and Actions, 32:10-21 (1991).
SCRIP, 1713:15 (1992).
Axton et al., "Novel Imminosuppressive Butenamides", J. Chem. Soc. Perkin Trans., 1:2203-2213 (1992).

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