Method for minimizing the uterothrophic effect of tamoxifen and

Details Method for minimizing the uterothrophic effect of tamoxifen and Method for minimizing the uterothrophic effect of tamoxifen and

1994-09-20

1996-09-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 5142392, 514428, 514648, A61K 31445, A61K 3155, A61K 31535, A61K 3140

Patent

active

055546285

ABSTRACT:
The present invention provides a method of minimizing the uterotrophic effect of non-steroidal antiestrogen compounds of formula II ##STR1## and wherein the variables are as defined in the specification and wherein said formula II compound is administered to a woman for the treatment or prevention of breast carcinoma, comprising concurrently or sequentially administering to said woman a compound of formula I ##STR2## wherein the variables are as defined in the specification.

REFERENCES:
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patent: 4380635 (1983-04-01), Peters
patent: 4418068 (1983-11-01), Jones
patent: 4623660 (1986-11-01), Richardson
Draper, M. W., et al., "Effects of Raloxifene (LY139481 HC1) on Biochemical Markers of Bone and Lipid Metabolism in Healthy Postmenopausal Women", Hong Kong, Fourth Int'l Symp. on Osteoporosis, Mar. 29, 1993.
Fisher, B., et al., JNCI, 86 (7):527-537 (1994).
Malfetano, J. H., Gynecol. Oncol., 37:82-84 (1990).
Kirkland, J. L., et al., Molecular Pharmacology, 43:709-714 (1993).
Wakeling, A. E., et al., J. Steroid Biochem., 20(1):111-120 (1984).
Jordan, V. C., et al., Ann. N.Y. Acad. Sci., 622:439-446 (1991).

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