Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of

Details Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of Use of 2-thioxo-imidazolin-4-one derivatives in the treatment of

1995-11-28

1996-09-10

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514326, 514341, 514422, 514430, 514431, 514432, 514444, 514449, 514450, 514451, 514461, 514824, A61K 31395, A61K 3155, A61K 31445, A61K 3144

Patent

active

055546072

ABSTRACT:
A method for increasing the HDL cholesterol concentration in the blood of a mammal in need of increased HDL cholesterol blood concentration, which comprises administering to said mammal, orally or parenterally, a compound of formula I: ##STR1## wherein R is alkyl; a substituted or unsubstituted aromatic N, O or S heterocycle; substituted or unsubstituted aryl, arylalkyl, benzhydryl or indanyl, in which the substituents are one to three members independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkenyl, alkynyl, halo, perfluoroalkyl, perfluoroalkyl or hydroxy; and R.sup.1 is aryl, alkyl, alkenyl, alkynyl or substituted aryl where the substituents are one to three members independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkenyl, alkynyl, halo, perfluoroalkyl, perfluoroalkoxy or hydroxy.

REFERENCES:
patent: 5137904 (1992-08-01), Baran et al.
patent: 5411981 (1995-05-01), Gaillard-Kelly et al.

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