Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-10-11
1996-09-10
Wityshyn, Michael G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514177, 514182, 514841, 514843, 530399, 530850, 530851, 530852, 530853, 530854, C07K 14575, C07K 1459, A61K 3156, A61K 3824
Patent
active
055545955
ABSTRACT:
Based on the discovery that normal pregnant mice have a striking reduction in committed precursors of B lymphocytes, which could be documented in mice as early as day 6 of gestation, when IL-7 responding colony forming cells were reduced as much as two-thirds of normal levels, it has been determined that estrogen and other hormones elevated in pregnancy induce a specific modulation of lymphocyte formation during pregnancy and lactation. It is therefore possible to immunomodulate in a specific manner an animal by administration of hormones elevated during pregnancy, such as estrogen and estrogen-like compounds, or antagonists of estrogen. This has potential in the treatment of a number of disorders, especially those found in very high percentages of women as compared with men, such as many of the autoimmune disorders, as well as in immune tolerance during pregnancy, cyclic neutropenia, and osteoporosis. There are also implications in culture of mammalian cells, since many of the culture medias include a dye such as phenol red as a pH indicator, which has estrogen-like properties, and animal sera which may not provide appropriate numbers and concentrations of hormones and therefore is not as beneficial for culture of cells which have responses similar to the lymphocytes.
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Le D
Kincade Paul W.
Medina Kay L.
Degen Nancy J.
Oklahoma Medical Research Foundation
Wityshyn Michael G.
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