Tricyclic fused pyrimidine derivatives, their production and use

Details Tricyclic fused pyrimidine derivatives, their production and use Tricyclic fused pyrimidine derivatives, their production and use

1990-02-15

1991-07-16

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544251, 540562, 514220, A61K 31505, C07D48714

Patent

active

050325949

ABSTRACT:
Novel tricyclic fused pyrimidine derivatives of the formula (I): ##STR1## wherein either one of R.sup.1 and R.sup.2 is hydrogen or an optionally substituted aralkyl group and the other is hydrogen, an optionally substituted aralkyl group or an aliphatic hydrocarbon group; R.sup.3 is hydrogen, an aliphatic hydrocarbon group or acyl group; and A is an optionally substituted divalent hydrocarbon chain having 2 to 4 carbon atoms and salts thereof are strong adenosine antagonists and activate cerebral functions and metabolisms, thus being useful as therapeutic or prophylactic agents for neurological or psychic changes caused by cerebral apoplexy, brain injury or cerebral atrophy.

REFERENCES:
patent: 3915976 (1990-10-01), Selmond
patent: 4603203 (1986-07-01), Furukawa et al.
patent: 4824848 (1989-04-01), Naka et al.
patent: 4912104 (1990-03-01), Naka et al.
Central Patents Index, Basic Abstracts Journal, Section B, 32972A/18 (Japanese Patent Publication Laid Open No. 31694/1978).

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