Cytokine-induced proliferation of amniotic t-cells

Details Cytokine-induced proliferation of amniotic t-cells Cytokine-induced proliferation of amniotic t-cells

1995-04-03

1999-03-09

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353723, C12N 500

Patent

active

058799370

ABSTRACT:
The invention provides improved methods of prenatal diagnosis that can be performed earlier in pregnancy, and/or with greater safety, and/or rapidity, and/or with greater accuracy than conventional methods. A volume of amniotic fluid containing fetal cells is extracted from a pregnant woman, and the fetal T-cells are propagated in a culture medium comprising one or more cytokines. The fetal T-cells are then diagnosed for genetic defects.

REFERENCES:
"Early Prenatal Diagnosis," British Medical Journal, 299:1211-1212, Nov. 11, 1989.
H. Brandenburg, et al., "Fetal Loss Rate After Chorionic Villus Sampling and Subsequent Amniocentesis," American Journal of Medical Genetics, 35:178-180, 1990.
Stephen J. Carlan, et al., "Effect of maternal-fetal movement on concentration of cells obtained at genetic amniocentesis," American Journal of Obstetrics and Gynecology, 163:490-493, Aug. 1990.
Winston W. Chen, "Studies on the origin of human amniotic fluid cells by Immunofluorescent staining of keratin filaments," Journal of Medical Genetics, 19:433-436, 1982.
S.K.F. Chong, et al., Subarachnoid Cyst With Hyderocephalus -A Complication of Mid-Trimester Amniocentesis, Prenatal Diagnosis, 9:677-679, 1989.
Fernand Daffos, "Access to the Other Patient," Seminars in Perinatology, 13(4):252-259, Aug. 1989.
B. Rafael Elejalde, et al., "Prospective Study of Amniocentesis Performed Between Weeks 9 and 16 of Gestation: Its Feasibility, Risks, Complications and Use in Early Genetic Prenatal Diagnosis," American Journal of Medical Genetics, 35:188-196, 1990.
Mark I. Evans, et al., "Genetic diagnosis in the first trimester: The norm for the 1990s," American Journal of Obstetrics and Gynecology, 160:1332-1339, 1989.
W. Furhmann, "Impact, logistics and prospects of traditional prenatal diagnosis, " Clinical Genetics, 36:378-385, 1989.
Eliane Gluckman, et al., "Hematopoietic Reconstitution in a Patient With Fanconi's Anemia by means of Umbilical-cord Blood From an HLA-Identical Sibling," The New England Journal of Medicine, 1174-1178, Oct. 26, 1989.
Izumi Hayashi, et al., "Replacement of serum by hormones permits growth of cells in defined medium," Nature, 259:132-134, Jan. 15, 1976.
Wolfgang Holzgreve, et al., "Genetic Aspects of Fetal Disease," Seminars in Perinatology, 13(4):260-277, Aug. 1989.
Helen M. Kingston, "Prenatal Diagnosis," British Medical Journal, 298(6684):1368-1371, May 20, 1989.
Tomas Leanderson, "Assays for Lymphokines Supporting B Cell Growth," Immunological Methods, 3:201-209, 1985.
David H. Ledbetter, et al., "Cytogenetic results of chorionic villus sampling: High success rate and diagnostic accuracy in the United States collaborative study," American Journal of Obstetrics and Genycology, 162:495-501, Feb. 1990.
G. Mandon, et al., "15 Years of Prenatal Diagnosis of Inherited Metabolic Diseases: the Lyon Experience," J. Inher. Metab. Dis., 12(2):257-259, 1989.
Giovanni Monni, et al., "Second-Trimester Placental Biopsy Versus Amniocentesis for Prenatal Diagnosis of .beta.-Thalassemia," The New England Journal of Medicine, 322(1):60-61, Jan. 4, 1990.
Hiroki Murakami, et al., "Growth of hybridoma cells in serum-free medium: Ethanolamine is an essential component," Proc. Natl. Acad. Sci. USA, 79:1158-1162, Feb. 1982.
J. Nevin, et al., "Early Amniocentesis: Experience of 222 Consecutive Patients, 1987-1988," Prenatal Diagnosis, 10:79-83, 1990.
R. Nisani, et al., "The Dilemma of Chromosomal Mosaicism in Chorionic Villus Sampling -`Direct` Versus Long Term-Cultures," Pernatal Diagnosis, 9:223-226, 1989.
Lawrence D. Platt, et al., "Prenatal Diagnosis -When And How?" The New England Journal of Medicine, 327(9):636-638, Aug. 27, 1992.
George G. Rhoads, et al., "The Safety and Efficacy of Chorionic Villus Sampling for Early Prenatal Diagnosis of Cytogenetic Abnormalities," The New England Journal of Medicine, 320(10):609-617, Mar. 9, 1989.
Angie Rizzino, et al., "Defined Media and the Determination of Nutritional and Hormonal Requirements of Mammalian Cells in Culture," Nutrition Reviews, 37(12):369-378, Dec. 1979.
D.E. Rooney, et al., "Tissue Culture Methods in Human Cytogenetics," Chapter 1:1-37, Human Cytogenetics: a practical approach, 1989, Oxford IRL Press, Washington, D.C.
D.E. Rooney, et al., "Early amniocentesis: a cytogenetic evaluation," British Medical Journal, 298(6690):25, Jul. 1, 1989.
Carl V. Smith, "Amniotic Fluid Assessment," Obstetrics and Gynecology Clinics of North America, 17(1):187-200, Mar. 1990.
Debra J. Wright, et al., "Interpretation of Chorionic Villus Sampling Laboratory Results is Just as Reliable as Amniocentesis," Obstetrics & Gynecology, 74(5):739-744, Nov. 1989.
P. Hohlfeld, M.D., "Toxoplasma Gondii Infection During Pregnancy: T Lymphocyte Subpopulations in Mothers and Fetuses," Pediatr. Infect. Dis. J., 9:878-881, 1990.
K. Nicolaides, et al., "Comparison of Chorionic Villus Sampling and Amniocentesis for Fetal Karyotyping at 10-13 Weeks' Gestation,", The Lancet, 344:435-439, 1994.
Laird G. Jackson, et al., "A Randomized Comparison of Transcervical and Transabdominal Chorionic-Villus Sampling," NE J. of Medicine, 327:594-598, Aug. 1992.
Marco Londei, et al., "Interleukin 7 is a Growth Factor for Mature Human T Cells," Eur. J. Immunol., 20:425-428, 1990.
J. Mendelsohn, et al., "Proliferation of Normal Human Lymphocytes in Serum-free, Albumin-free Medium," in D. Sirbasku, et al., eds., Proceedings of Cold Spring Harbor Conference on Cell Proliferation, Growth of Cells in Hormonally Defined Media, 9:677-690, 1982.
M. B. Widmer, et al., "Lymphopoiesis and IL-7," Int. J. of Cell Cloning, 8:168-172, Supp. 1, 1990.

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