Treating inflammation via the administration of specific sulfata

Details Treating inflammation via the administration of specific sulfata Treating inflammation via the administration of specific sulfata

1997-08-19

1999-07-20

Prats, Francisco

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424 946, 424 941, 424662, 424702, 435196, 435200, A61K 3847, A61K 3843, A61K 3304, A61K 3320

Patent

active

059253495

ABSTRACT:
Compositions are administered to a patient (preferably by injection and locally) to treat a variety of conditions including inflammation associated with trauma and with certain aspects of diseases such as rheumatoid arthritis, psoriasis, insulin-dependent diabetes, cutaneous lymphomas, duodenal ulcer, chronic proctitis, lymphocytic thyroiditis, hemorphagic shock, reperfusion injury during transplantation and multiple sclerosis. The compositions are pharmaceutically acceptable injectable formulations which include an active component in a pharmaceutically acceptable carrier. The active component is a chlorate or selenate which inhibits the natural biochemical sulfation process and/or a sulfatase enzyme which removes a sulfate from a specific position of a saccharide molecule which makes up a part of a natural ligand for L-selectin. Removal of the sulfate from the ligand hinders the ability of the ligand to bind to its natural receptor (i.e. L-selectin) and thereby hinders a biochemical chain of events which results in inflammation.

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