Method of screening for inhibitors of human thyrotropin releasin

Details Method of screening for inhibitors of human thyrotropin releasin Method of screening for inhibitors of human thyrotropin releasin

1994-08-09

1999-03-09

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 721, 435 691, 530350, 536 235, 436500, G01N 3353, G01N 33566

Patent

active

058798960

ABSTRACT:
A human receptor protein capable of binding TRH, a DNA coding for said protein, use of the proetein and DNA, a method for preparing said protein, and antibodies to the protein are described.
The human TRH receptor protein and the DNA coding for the protein of the present invention are useful as (1) a diagnostic composition for neuropathy (particularly, dementia), (2) a pharmaceutical composition for neuropathy and (3) a material used for screening a TRH receptor agonist or antagonist.

REFERENCES:
patent: 5288621 (1994-02-01), Gershengorn et al.
Dorland's Illustrated Medical Dictionary (1994) W. B. Saunder's Company, Philadelphia, pp. 1714-1715.
Le Dafniet, M. et al. (1985) Horm. Metabol. Res. 17:476-479.
Watson, S. et al. (1994) The G-Protein Linked Receptor Factsbook, Academic Press, San Diego, pp. 275-277, 297, 335-339.
Drummond, A. H. (1985) Biochem. Biophys. Res. Comm. 127:63-70.
De Marinis, L. et al. (1990) Acta Endocrinol. 122:433-449.
Endocrinology vol. 128 No. 2, 1991, pp. 1204-1206 Gershengorn M.C. et al. Regulation of Thyrotropin-Releasing Hormone Receptors in Cell Type Specific Comparison of Endogenous Pituitary Receptors and Receptors Transfected into Non-Pituitary Cells.
Ann New York Acad Sci vol. 553, May 8, 1989, pp. 147-175; Sharif. N.A. Quantitative Autoradiography of TRH Receptors in Discrete Brain Regions of Different Species.
Brain Research 563 vol, Jun. 1991, pp. 66-76 Najimi et al. Autoradiographic distribution of TRH binding sites in the Human Hypothalamus.
V. Matre et al., Biochemical and Biophysical Research Communications, 195(1): 179-185 (1993).
P. Pena et al., The Journal of Biological Chemistry, 267(36): 25703-25708 (1992).
Pamphlet of Medical Research Council (MRC) "Human TRH Receptor".
M. Yamada et al., Biochemical and Biophysical Research Communications, 195(2): 737-745 (1993).
R. Straub et al., Proc. Natl. Acad. Sci. USA, 87: 9514-9518 (1990).
P. de la Pena et al., Biochemical Journal, 284: 891-899 (1992).

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