Chemistry: electrical and wave energy – Apparatus – Electrolytic
Patent
1986-09-17
1988-05-10
Kaplan, G. L.
Chemistry: electrical and wave energy
Apparatus
Electrolytic
204418, 427 58, G01N 2730
Patent
active
047433523
ABSTRACT:
A sensor arrangement for monitoring ionic concentrations in fluids uses anion-selective membrane formed of N,N'-dibenzyl-N,N'-diphenyl-1,2-phenylenedioxydiacetamide suspended in an inert carrier, such as PVC having a high molecular weight. The membrane is disposed on a porous ceramic plug which permits wetting of the side of the membrane facing the plug with an internal fluid of the system, such as saline. The other side of the membrane communicates with the fluid to be assayed, which in certain intravenous embodiments may be the blood of a patient. In one embodiment, the system is provided with a reference electrode which is arranged to communicate with the fluid being monitored via a dialysis membrane. High impedance electronic circuitry produces a signal indicative of the ionic concentration in response to a potential appearing across the reference and sensor electrodes. The electronic circuitry has wide range offset and gain controls which are independent of one another, while maintaining the circuitry simple and safe for connection to a patient.
REFERENCES:
patent: 3103480 (1963-09-01), Watanabe et al.
patent: 3622745 (1972-05-01), Cosentino
patent: 3957612 (1976-05-01), Niedrach et al.
patent: 4236987 (1980-12-01), Schindler et al.
patent: 4314895 (1982-02-01), Spaziani et al.
patent: 4340457 (1982-07-01), Kater
patent: 4366038 (1982-12-01), Kearney et al.
patent: 4379041 (1983-04-01), Petranek et al.
patent: 4486290 (1984-12-01), Cahalan et al.
patent: 4504368 (1985-03-01), Delton et al.
patent: 4505800 (1985-03-01), Toner et al.
patent: 4519973 (1985-05-01), Cahalan et al.
patent: 4565665 (1986-01-01), Fogt
patent: 4565666 (1986-01-01), Cahalan et al.
patent: 4568444 (1986-02-01), Nakamura et al.
O. S. Anderson, "Factors Affecting the Liquid Junction Potential in Electrometric Blood pH Measurement," Scandinav. J. Clin. & Lab. Investigation, pp. 205-211, vol. 13, 1961.
O. H. LeBlanc et al., "Polymer Membrane Sensors for Continuous Intracascular Monitoring of Blood pH," Journal of Applied Physiology, pp. 644-647, vol. 40, No. 4, Apr. 1976.
D. M. Band et al., "Theory of Potassium Ion Selective Electrode," Intensive Care Medicine, pp. 50-52, 1977.
Treasure et al., "A Catheter Tip Potassium-Selective Electrode," Journal of Medical Engineering and Technology, pp. 271-273, Sep. 1977.
Band et al., "Relationship between Activity and Concentration of Plasma Potassium," Analyst, pp. 426, 251, vol. 103, Mar. 1978.
Cobbe et al., "Continuous Measurement of pH in Central Arteries and Veins," The Lancet, pp. 444-445, Sep. 1, 1979.
Bird et al., "Intravascular Complications of Transurethral Resection of the Prostate," pp. 564-565, vol. 54, 1982.
Sunderrajan et al., "Posttransurethral Prostatic Resection Hyponatremic Syndrome: Case Report and Review of the Literation," American Journal of Kidney Diseases, pp. 80-84, vol. IV, No. 1, Jul. 1984.
Dutsch, et al., "Microprocessor-Controlled ex Vivo Monitoring of Sodium and Potassium Concentrations in Undiluted Urine with Ion-Selective Electrodes," Anal. Chemistry, pp. 578-580, vol. 57, 1985.
Fogt et al., "Response of Ion-Selective Field Effect Transistors to Carbon Dioxide and Organic Acids," Anal. Chem., pp. 1995-1998, vol. 57, 1987.
Heuser et al., "Ionic Changes in Brain Ischemia and Alterations Produced by Drugs," Br. J. Anaesth., pp. 23-33, 1985.
Simon et al., "Ion-Selective Electrodes and Their Clinical Application in the Continuous Ion Monitoring," Annals of the New York Academy of Sciences, pp. 279-285, vol. 428.
Kaplan G. L.
The University of Michigan
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