Delivery of therapeutic agents to receptors using polysaccharide

Details Delivery of therapeutic agents to receptors using polysaccharide Delivery of therapeutic agents to receptors using polysaccharide

1994-06-16

1996-09-10

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424646, 435178, 514 2, 514 21, 514 54, 514169, 514179, 536 551, A61K 4726, A61K 3156, A61K 31495, A61K 3170, A61K 39395, A61K 3326, A61K 3821

Patent

active

055543863

ABSTRACT:
This invention relates to a method of directing a therapeutic agent to selected cells, wherein a complex is formed between a polysaccharide capable of interacting with a cell receptor and a therapeutic agent. The resulting complex is administered to a subject, and permitted to be internalized into the selected cells through a process known as receptor mediated endocytosis (RME). The polysaccharide may be, for example, arabinogalactan, gum arabic, mannan or hydrolysis products thereof; the therapeutic agent may be, for example, an antiviral agent, a nucleic acid, hormone, steroid, antibody, chemoprotective or radioprotective agent. The cell receptor may be for example, the asialoglycoprotein receptor or the mannose receptor.

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