Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1995-06-07
1999-03-09
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424455, 424 45, 424 43, A61K 914
Patent
active
058797122
ABSTRACT:
Method of producing microparticles loaded with biologically active drugs, including proteins such as ICAM-1, for controlled release of the drugs in a nasal passageway. The method includes introducing a drug/polymer feed solution and an emulsifier into a first mixing chamber to create an emulsion, then mixing a cross-linking agent together with the emulsion under controlled conditions to create microparticles loaded with the drug in a second mixing chamber. The formed microparticles are filtered and deaggregated to form individual microparticles that then may be formulated for nasal passageway delivery.
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Bomberger David C.
Catz Paul G.
Smedley Mark I.
Stearns Paul C.
Benston, Jr. William E.
Luther Barbara J.
Page Thurman K.
SRI - International
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