Process for the preparation of 3-cyanochromones

Details Process for the preparation of 3-cyanochromones Process for the preparation of 3-cyanochromones

1978-12-13

1980-04-01

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D31122

Patent

active

041961285

ABSTRACT:
3-cyanochromones having the following structural formula I: ##STR1## wherein R represents hydrogen, halogen or lower alkoxy, are prepared by dehydrating chromone-3-carboxamides with thionyl chloride in N,N-dimethylformamide. The compound having formula I is useful as an anti-allergic and anti-secretory agent.

REFERENCES:
patent: 3825574 (1974-07-01), Brown
patent: 3849446 (1974-11-01), Strandtmann et al.
patent: 3853921 (1974-12-01), Klutchko et al.
patent: 3862143 (1975-01-01), Klutchko et al.
patent: 3879411 (1975-04-01), Cairns et al.
patent: 4116971 (1978-09-01), Strandtmann et al.
Ellis et al., Prog. Med. Chem. 9, pp. 93-94 (1973).
Ellis et al., J. Med. Chem., 15, 865 (1972).
Ellis, "Chromenes, Chromanones and Chromones," John Wiley & Sons (New York), p. 905.

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