N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids

Details N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids

1994-05-04

1995-06-13

Henley, III, Raymond

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549429, 549491, 556 12, 558175, 558169, 558166, 558145, C07F 948, A61K 3166

Patent

active

054244412

ABSTRACT:
N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids of formula I ##STR1## wherein R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radical having at least 2 carbon atoms, R.sub.1 is hydrogen or hydroxy, R.sub.2 is an araliphatic or heteroarylaliphatic radical substituted by free or functionally modified carboxy that is bonded directly or by way of a spacer, and R.sub.3 is hydrogen, lower alkyl or a group R.sub.2, and the salts thereof have valuable nootropic and anti-epileptic properties and can be used in the preparation of a nootropic or anti-epileptic medicament.

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