Indole-2-carboxamides as inhibitors of cell adhesion

Details Indole-2-carboxamides as inhibitors of cell adhesion Indole-2-carboxamides as inhibitors of cell adhesion

1993-08-18

1995-06-13

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514419, 548483, 548484, A61K 3140

Patent

active

054243297

ABSTRACT:
3-Substituted-indole-2-carboxamides are described as agents which inhibit leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these compounds are novel and methods of manufacture are also described.
Certain of the indole-2-carboxamides also inhibit the activation of human immunodeficiency virus (HIV), latent in infected humans.

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