Resolution of racemic mixtures

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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564304, C07B 5700

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active

049688375

ABSTRACT:
Racemic 2-(N-propylamino)-5-methoxytetralin is resolved by treating it with a chiral diaroyltartaric acid in an organic solvent at an elevated temperature to form a salt of the amine and chiral diaroyltartaric acid which is soluble in the solvent at the elevated temperature, cooling to precipitate the salt, isolating it, and converting it to the free amine. The product is useful as an intermediate in the synthesis of optionally-active pharmaceutical, such as N-0437.

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Gerding et al., Journal of High Resolution Chromatography & Chromatography Communications, vol. 10, pp. 523-525, Sep. 1987.

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