Process for the preparation of nitroethene derivatives

Details Process for the preparation of nitroethene derivatives Process for the preparation of nitroethene derivatives

1988-04-01

1990-11-06

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549495, C07D27728, C07D30752

Patent

active

049688081

ABSTRACT:
A new process for the preparation of the nitroethane derivatives, ranitidine and nizatidine, is described which takes place via intermediate products and enables the said compounds to be prepared with a higher degree of purity. Another advantage is that in contrast to the known processes, it is not accompanied by the liberation of the highly toxic and malodorous compound, methylmercaptan.

REFERENCES:
patent: 4233302 (1980-11-01), Smith
patent: 4760075 (1988-07-01), Pioch
patent: 4777260 (1988-10-01), Ryan
Rudchenko, Zh Org. Khim. 13, 1383 (1977) Abstract.
Buevich, Zh Org. Khim, 13, 2618 (1977) Abstract.

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