Substituted di-t-butylphenols and anti-allergic use thereof

Details Substituted di-t-butylphenols and anti-allergic use thereof Substituted di-t-butylphenols and anti-allergic use thereof

1988-09-26

1990-11-06

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514532, 514534, 514568, 548252, 562432, A61K 3141, A61K 3119, C07D25704, C07C 6500

Patent

active

049687107

ABSTRACT:
Novel compounds which are 2,6-di-t-butylphenols substituted in the 4 position by an alkoxy or benzyloxy group or a benzylthio group, which alkoxy or benzyloxy group is directly substituted by a tetrazole ring, and which benzylthio group is directly substituted by carboxy or tetrazolyl are useful as inhibitors of leukotriene biosynthesis and as antiallergic agents. Synthetic intermediates for preparing such compounds are also described.

REFERENCES:
patent: 3674836 (1972-07-01), Creger
patent: 4675334 (1987-06-01), Steggles et al.
patent: 4677113 (1987-06-01), Bell et al.
patent: 4710515 (1987-12-01), Kirk et al.
patent: 4714776 (1987-12-01), Bell et al.

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