Pyridine compounds which are useful as anti-arrhythmic agents

Details Pyridine compounds which are useful as anti-arrhythmic agents Pyridine compounds which are useful as anti-arrhythmic agents

1989-08-14

1990-11-06

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514343, 546194, 546281, A61K 31445, C07D21302

Patent

active

049687042

ABSTRACT:
A series of novel aryloxyalkylamino- and arylaminoalkylamino-pyridine and imidazole compounds have been prepared, including their pharmaceutically acceptable salts, wherein the aryl moiety is further substituted by a sulphamoyl or sulphonylamino group or by a ureido or acylamino group located at the para-position of the ring with respect to the aforesaid alkylamino side chain. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. Methods for preparing all these compounds from known starting materials are provided.

REFERENCES:
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patent: 3253921 (1966-05-01), Sawdey
patent: 3692525 (1972-09-01), Hartigan
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patent: 3738837 (1973-06-01), Kuwabara
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patent: 3813255 (1974-05-01), Mannens
patent: 4195999 (1980-04-01), Adachi
patent: 4386037 (1983-05-01), Baumann
patent: 4696888 (1987-09-01), Buhr

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