Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-09-08
1990-11-06
Ore, Dale R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514275, 514356, 514880, 514881, A61K 706, A61K 910, A61K 31505, A61K 3144
Patent
active
049686852
ABSTRACT:
The invention relates to a composition for inducing and stimulating hair growth and retarding its loss, containing, in a cosmetically or pharmaceutically acceptable medium, at least one pyrimidine derivative corresponding to the formula (I): ##STR1## in which R.sub.1 denotes a group ##STR2## in which R.sub.3 and R.sub.4 can be chosen from hydrogen, an alkyl group preferably having 1 to 4 carbon atoms, and an alkenyl, alkylaryl or lower cycloalkyl group, and R.sub.3 and R.sub.4 can also form a heterocyclic ring with the nitrogen atom to which they are attached, it being possible for this heterocyclic ring to be chosen, inter alia, from aziridinyl, azetidinyl, pyrrolidinyl, piperidyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine and 4-(lower alkyl)piperazidinyl groups, it being possible for the heterocyclic groups to be substituted on the carbon atoms with one to three lower alkyl, hydroxyl or alkoxy groups; the group R.sub.2 is chosen from hydrogen and an alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl and lower haloarylalkyl group, or one of its addition salts with cosmetically or pharmaceutically acceptable acids, and at least one nicotinic ester.
REFERENCES:
patent: 2431558 (1947-11-01), Huber
patent: 3168438 (1965-02-01), Halpern
patent: 3461461 (1969-08-01), Anthony et al.
patent: 4139619 (1979-02-01), Chidsey, III
patent: 4329338 (1982-05-01), Szego et al.
patent: 4596812 (1986-06-01), Chidsey, III et al.
Current Therapy, pp. 599-602 (1984).
Current Therapy, p. 662 (1981).
Patent Abstracts of Japan, vol. 7, No. 185 (C-181) [1330], Aug. 13, 1983.
"L'Oreal"
Ore Dale R.
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