Pyridine-2,4- and 2,5-dicarboxylic acid derivatives, a process f

Details Pyridine-2,4- and 2,5-dicarboxylic acid derivatives, a process f Pyridine-2,4- and 2,5-dicarboxylic acid derivatives, a process f

1988-02-08

1990-11-06

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514354, 530331, 546323, A01K 3144, C07D21381

Patent

active

049686704

ABSTRACT:
Pyridine-2,4- and 2,5-dicarboxylic acid derivatives, a process for their preparation, the use thereof, and medicaments based on these compounds.
The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and X have the indicated meanings, to a process for the preparation of these compounds, and to their use, in particular in medicaments for influencing the metabolism of collagen and collagen-like substances and the biosynthesis of C1q.

REFERENCES:
W. Muller et al., FEBS Lett. 90 (1978), 218; Immunobiology 155 (1978) 47.
A. Hubbuch, Schutzgruppen in der Peptidsynthese (Teil 1): Schutzgruppentaktik, Amino- und Carboxyl-Schutzgrupen, Kontakte 3/79, pp. 15 & 19 et seq.
Houben-Weyl, Methoden der Organischen Chemie (Methods of Organic Chemistry), vol. E5, pp. 496-504, 4th Ed., 1985.
Houben-Weyl, Methoden der Organischen Chemie, vol. XV/2, pp. 103-111, 4th Ed., Georg Thieme Verlag, Stuttgart, 1974.
Organikum, Organisch Chemisches Grundpraktikum (Basic Techniques of Organic Chemistry), 15th Ed., VEB Deutscher Verlag der Wissenschaften, 1976, pp. 595 et seq.
Houben-Weyl, Methoden der Organischen Chemie, vol. XV/2, pp. 169-183, 4th Ed., 1974, Georg Thieme Verlag Stuttgart.
W. Muller et al., FEBS Letters, vol. 90, 1978, p. 218.
K. Majamaa et al., Eur. J. Biochem., vol. 138, 1984, pp. 239-245.
V. Gunzler et al., Collagen and Rel. Research, vol. 3, p. 71, 1983.
The Liver, C. Rouiller, vol. 2, pp. 335-476, New York, Academic Press, 1964.
Talma et al., Journal of the American Chemical Society, vol. 107, pp. 3981-3997 (1985).
Atwell et al., Journal of Medicinal Chemistry, vol. 10, No. 4, pp. 706-713 (Jul. 1967).

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