Parathyroid hormone antagonists

Details Parathyroid hormone antagonists Parathyroid hormone antagonists

1989-04-21

1990-11-06

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, C07K 710, A61K 3743

Patent

active

049686690

ABSTRACT:
The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone. The structure of the peptide hormone analogues is exemplified by parathyroid hormone wherein Gly.sup.12 is substituted by D-Trp, L-Trp, L- or D- alpha- or beta-naphthylalanine, or D- or L- alpha-MeTrp.

REFERENCES:
Caporale et al. "Characterization of PTH Antagonists". Pept.: Chem. Biol., Proc. Am. Pept. Symp. 10th Mtg. 449-51 (1988).

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