Method and test kit for detection of antibodies

Details Method and test kit for detection of antibodies Method and test kit for detection of antibodies

1989-07-20

1990-11-06

Nucker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

422 56, 422 61, 435805, 436530, 436531, 436808, 436809, 436810, G01N 33535, G01N 33545

Patent

active

049686046

ABSTRACT:
Assay methods and test kits for detection of antibodies having specificities for a variety of determinants in patient samples are disclosed. The assay is especially suitable for use in evaluating patients for their suitability to receive diagnostic and therapeutic immunoconjugates comprising immunoglobulin constituents derived, at least in part, from a non-human source. The assay methods and test kits utilize a target substance (e.g., immunoglobulin) which has substantially the same binding characteristics as a portion of the immunoconjugate proposed for in vivo administration. A plurality of target substance densities are used for assaying each patient specimen to provide an indication of both the level and relative affinity of circulating antibody capable of binding to the immunoconjugate proposed for treatment. According to preferred embodiments, the assay utilizes a dipstick or test strip format wherein multiple densities of a target substance are bound to a support medium in a predetermined spatial relationship, preferably in a side-by-side relationship.

REFERENCES:
patent: 2278339 (1940-01-01), Vollmer
patent: 4157895 (1979-06-01), Finlay et al.
patent: 4654310 (1987-03-01), Ly
Schroff et al., "Human Anti-Murine Immunoglobulin Responses in Patients Receiving Monoclonal Antibody Therapy", Cancer Res. 45(1985), 879-885.

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