Ethanethioates and mercaptoamides and use thereof as analgesic a

Details Ethanethioates and mercaptoamides and use thereof as analgesic a Ethanethioates and mercaptoamides and use thereof as analgesic a

1984-02-06

1986-01-28

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

564192, 564218, 260455R, 514625, 548195, A61K 31265, A61K 3116, C07C10312, C07C153023

Patent

active

045671982

ABSTRACT:
Novel analgesic and enkephalinase inhibiting compositions comprising an analgesically and enkephalinase inhibitory effective amount of at least one compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and acetyl, n is 1 or 2 and when n is 1, R.sub.2 is selected from the group consisting of phenyl, p-chlorophenyl, m-trifluoromethylphenyl and thiazolyl and when n is 2, R.sub.2 is selected from the group consisting of phenyl and p-chlorophenyl and their salts with non-toxic, pharmaceutically acceptable acids and bases and an inert pharmaceutical carrier and novel method of relieving pain and inhibiting enkephalinase activity in warm-blooded animals and novel amides.

REFERENCES:
patent: 3093146 (1963-06-01), Kalopissis et al.

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