Process for preparing erythromycin succinate

Details Process for preparing erythromycin succinate Process for preparing erythromycin succinate

1979-06-14

1980-08-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 17R, 424180, C07H 1708, A61K 3170

Patent

active

042196418

ABSTRACT:
A rapid and efficient process for preparing the useful antibiotic erythromycin ethyl succinate in high yield which comprises reacting erythromycin USP quality free base with ethyl succinyl chloride in a two phase system consisting of an organic solvent which is capable of forming two phases with water or an aqueous base, and an aqueous base.

REFERENCES:
patent: 2857312 (1958-10-01), Stephen
patent: 2967129 (1961-01-01), Clark
patent: 3853842 (1974-12-01), Kishi et al.

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